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Think of them like eyeglasses for your feet: while you're wearing them, the structural problem driving your fascia strain is compensated for the force is redistributed, the arch is supported, and the fascia gets a break it couldn't get on its own

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This is also accompanied by only a 25% reduction in the NADPH:NADP + ratio [61]

Although it could be theoretically possible to enhance the reverse cholesterol effects of LXRs without targeting hepatic lipogenesis with the use of LXR-specific ligands since most of the hepatic responses are due to activation of LXR, this will be a difficult challenge as the ligand binding pocket in both isoforms has been shown to be nearly identical