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Specifically, transcriptional changes arising from rare cell populations or spatially localized regions may be diluted or overlooked

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Repeated injection can also damage veins
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Trans-translation and protein degradation systems Trans-translation exists in almost all bacteria, and plays an important role in rescuing stranded ribosomes and degrading toxic proteins during protein translation

This reduces the psychosomatic component of the condition (see: How histamine intolerance affects the psyche)
