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Tirzepatide (Mounjaro/Zepbound) achieves the greatest weight loss at 20.9%, followed by semaglutide 2.4mg (Wegovy) at 14.9%, then liraglutide 3.0mg (Saxenda)...

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Conclusions Combination of SGLT2i and GLP-1RA achieved significantly better cardiometabolic outcomes compared with SGLT2i alone

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Future research should focus on elucidating the complex mechanisms underlying their psychological effects and integrating mental health considerations into therapeutic strategies

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