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Fuciarelli, J
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Cyanocobalamin also helps maintain nerve health
Unlike its cyclic counterpart Melanotan II, MT-1 retains a linear backbone analogous to the 13-amino-acid natural -MSH sequence, differing primarily in a norleucine substitution at position 4 and a D-phenylalanine at position 7 (Nle-D-Phe--MSH), which confer receptor selectivity and enhanced metabolic stability
Its primary allegiance is to the Melanocortin 1 Receptor (MC1R)
Similarly, siRNA-mediated knockdown of dystroglycan or its glycosylation regulator LARGE abolished adhesion to laminin-211
