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However, after administration of necroptosis and ferroptosis inhibitors on top of the CDE diet, it was found that ferroptosis inhibitors almost completely reversed hepatocyte death, whereas necroptosis inhibitors failed to block the onset of cell death, suggesting that hepatocyte ferroptosis may be one of the initial modes of cell death at the onset of steatohepatitis and may be a trigger for the initial inflammation of steatohepatitis [135]

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Although the meristematic cells can potentially divide for a long time, most cells divide only several times before they escape meristem and are substituted by new cells arising from apical cells