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( c, d ) The relative FLVCR1b mRNA level ( c ) and the heme concentration ( d ) in MCF-7 cells treated with 100 M H2O2 or 5 mM NAC were measured

This observation has been reported in a wide range of cancers, including breast [47], lung [48], pancreas [49], colorectal [50] and oral [51]

doi: 10.1038/s41467-024-51736-5 112 ZhangJDongYYuSHuKZhangLXiongMet al

By the very nature of their biological tasks, the liver, cardiovascular system, and immune system all require extensive antioxidant support on a daily basis.* All human cells can produce glutathione, but its production can be challenged by cysteine availability in the diet

In this review, we consider the significance of mitochondrial oxidative stress on the pathogenesis of kidney disease, including CKD and AKI, with a focus on the role of Mn-SOD dysfunction
