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Timothy Piatkowski, a National Health and Medical Research Council emerging leadership fellow from the school of public health at the University of Queensland, Australia, tells us that the synthetic peptide trend is comparable to the rise of GLP-1 weight loss drugs as seen in the case of the unapproved triple agonist retatrutide

Regarding thyroid effects: rodent studies with related GLP-1 receptor agonists have shown C-cell changes, but no causal link to thyroid tumours in humans has been established in UK or EU regulatory assessments

Applies to many compounded drugs, not just weight-loss medications

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Liraglutide can decrease SBP by 1.2 mmHg [8]

It has been reported that the treatment of diabetic animal models with exendin-4 can improve bone mechanical properties and prevent bone loss by changing the cortical microstructure and bone composition parameters (mineral crystallinity, collagen maturity, acid phosphate content, and carbonphosphorus ratio) (Mansur et al., 2019)