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Turkovic et al., 2004), as well as maintained NO system function against NOS blockade (L-NAME) or overfunction (L-arginine) (for review, see Sikiric et al., 2014)

The resulting lipopeptide, known as EK1C4, showed 226-fold higher binding affinity for the HR1 domain and about 240-fold higher antiviral activity against SARS-CoV-2 than EK1 alone [77]

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Phase 1 is believed to correspond to the high level of activity in the primary afferent as by C-fiber activation due to peripheral stimulation, 9 whereas phase 2 seems to result from the continuous low level of small afferent input, together with a facilitated state of spinal processing