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This influence is primarily mediated by the autonomic nervous system (ANS), which regulates various aspects, including gut permeability, regional gut motility, intestinal transit and secretion

Although intestinal paracellular junctions have been observed histologically and their function measured for decades, they were initially thought to be static structures

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Further investigation is necessary to determine whether the ferroptosis of specific types of immune cells in the intestine plays a role in the development or advancement of intestinal diseases