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A 2015 study published in the Annals of Clinical and Laboratory Science found that intra-articular (injected into the joint) AOD-9604 enhanced cartilage regeneration in a rabbit model of knee osteoarthritis

[2] In DIO mice, 5-Amino-1MQ was reported to reduce body weight and white adipose mass and to lower plasma cholesterol, without a measured change in food intake

This page covers both, with the oral route first

Exenatide trials for the treatment of type 2 diabetes

Validation of diacylglycerolacyltransferase I as a novel target for the treatment of obesity and dyslipidemia using a potent and selective small molecule inhibitor

So, keep that water bottle handy and sip throughout the day