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8 A case-control study that compared 25,956 patients who had vitamin B 12 deficiency with 184,199 control patients found a significantly increased risk of vitamin B 12 deficiency in patients who had taken proton pump inhibitors (odds ratio = 1.65) or histamine H 2 blockers (odds ratio = 1.25) for at least two years

Combining them at a 1:1 ratio is a formulation approach designed to address both the follicle cell layer and the scalp structural layer simultaneously

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Such conditions include liver diseases, especially alcoholic liver disease and chronic hepatitis