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Studies in islets of phospholipase C and Epac knockout mice also suggest that Epac2 acts via Rap1-regulated phospholipase C to cause calcium-induced insulin exocytosis (Shibasaki et al., 2007

The Zepbound cases in the GLP-1 federal MDL are moving through expert work on key cross-cutting issues, with expert reports due in early 2026 and expert depositions currently scheduled to be completed by April 10, 2026, followed by Rule 702 motions and summary judgment briefing through mid-2026

Some plans require prior authorization or step therapy (trying other options first)

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Here we analyzed 10,960 individuals from 9 multiancestry biobank studies across 6 countries to assess the impact of known genetic factors on weight loss

A more comprehensive strategy is required