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Thyroid issues, such as risk of C-cell tumors, have been seen in animal studies (but not yet humans)

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Due to the emerging role of NAD homeostasis in aging and age-related diseases, our discovery of the role of CD38 in the control of cellular NAD levels opens the possibility that CD38 inhibition may be used as a therapeutic approach to increase cellular NAD levels (Figure 1)[1-4, 6]

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