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PTCH1 has been shown to trigger apoptosis through the DRAL-caspase-9 complex in the absence of Shh ( A recent study ( 3.6 Endogenous hydrogen sulfide pathway Endogenous hydrogen sulfide (H 2 S) is produced from L-type cysteine (L-Cys) or homocysteine under the catalysis of cystathionine--synthase (CBS), cystathionine--lyase (CSE) or 3-mercaptopyruvate sulfurtransferase (3-MST)

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