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During cardiac stress, ischemic injury, and metabolic syndrome in the cardiovascular system, necrotic cells release DAMPs, which are recognized by pattern recognition receptors on innate immune cells, triggering strong inflammatory responses

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Moreover, early studies on HIV-1-infected subjects associated GSH deficiency with a poor lymphocytic response and impaired survival following HIV-1 infections 28,29,30 , implying a role for GSH in disease

The labile iron within the endosomes is transported to the cytoplasm via DMT1 after conversion to Fe 2+ by a member of the Six transmembrane epithelial antigen of the prostate (STEAP) family of reductase proteins [16]