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Physiological Function of NNMT and the Related Metabolic Pathways NNMT is a cytosolic enzyme that catalyzes NA methylation using S-adenosyl-methionine (SAM) as a methyl donor, while producing 1-methylnicotinamide (MNA) and S-adenosyl-homocysteine (SAH)
In vitro , they found that NNMT knockdown and NNMT inhibition by MNA both significantly increase the oxygen consumption in adipocytes
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