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There is a decrease in mitochondrial DNA coupled with mitochondrial DNA damage, mediated by 8-oxo-7,8-dihydro-29-deoxyguanosine (8-OhdG) accumulation in patients with AD (Figure 2C) (de la Monte et al., 2000

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Halaris et al

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Both the ciliary body and retina have direct access to blood vessels and are also known to be more sensitive to oxidative stress, increasing the risk in these areas for a variety of oxidative stress-induced eye diseases

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These studies have identified numerous plant metabolites and derivatives that target multiple pathways and molecular targets

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15 :e17198 43

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Mutation of the metal-binding aspartate results in an inactive SelO enzyme

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