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There is a decrease in mitochondrial DNA coupled with mitochondrial DNA damage, mediated by 8-oxo-7,8-dihydro-29-deoxyguanosine (8-OhdG) accumulation in patients with AD (Figure 2C) (de la Monte et al., 2000

Halaris et al

Both the ciliary body and retina have direct access to blood vessels and are also known to be more sensitive to oxidative stress, increasing the risk in these areas for a variety of oxidative stress-induced eye diseases

These studies have identified numerous plant metabolites and derivatives that target multiple pathways and molecular targets

15 :e17198 43

Mutation of the metal-binding aspartate results in an inactive SelO enzyme
