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The key stroke registration data come from multi-centre Russian clinical trials in the 1990s and 2000s, showing reduced neurological deficit on standardised rating scales and improved functional recovery when intranasal Semax 1 percent was added to standard acute-stroke care within the first 24 hours of symptom onset

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Vagal afferent stimulation activates astrocytes in the nucleus of the solitary tract via AMPA receptors: evidence of an atypical neural-glial interaction in the brainstem

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doi: 10.3389/fimmu.2023.1166487 32 MantovaniAAllavenaPMarchesiFGarlandaC

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