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p = 0.41), while simultaneously the correlation between both these metabolites (but especially the 2-methoxyestrogens) and the 2-OH-DNA adducts became stronger and significant (2-hydroxyestrogens: r = 0.42

Meiotic cohesin STAG3 is required for chromosome axis formation and sister chromatid cohesion

Downmodulation of the NRF2 pathway was also confirmed by RT-qPCR analyses of four known NRF2 transcriptional targets ( GCLM , GSR , NQO1 , and MGST1 ) in both Hs 578T and MDA-MB-231 TNBC cells, showing reduced expression of these genes upon Cyss deprivation (Fig

NADPH is important for not only biosynthesis of fatty acids and cholesterol but also generation of reduced glutathione (GSH)

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