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Description
Under normal conditions, NRF2 is bound to Kelch-like ECH-associated protein 1 (Keap1) in the cytosol
Furthermore, excess glutamate competes with cysteine at the glutamate-cysteine pump, resulting in eventual glutathione depletion and the production of toxic free radicals
doi: 10.1371/journal.pone.0015218
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Why Does It Matter
Some patients with vascular parkinsonism or white-matter disease need a separate review of neurovascular conditions such as CSVD, because the treatment discussion is different from idiopathic PD
10.1016/0168-6445(95)00011-Z FEMS Microbiol Rev
