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Hypoxia induces HIF1-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy

A 1% serum in an opaque airless bottle with a clean formula will usually outperform a poorly stabilized 3% serum that has oxidized on a shelf

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To investigate whether inhibition of Gpx induces T-cell hyporesponsiveness, we pretreated 0.4 mM MS (Gpx inhibitor, Sigma-Aldrich) for 48 h, then treated Con A (5 g/ml) for 8 h in Jurkat T cells

doi: 10.1016/0891-5849(94)90092-2