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All the mice were weighed and gavaged orally at 200 mg/kg body weight with freshly prepared 2

RP/HPLC analysis of this preparation on a C18 column followed by protein deconvolution indicated M pro was now a mixture of mono (23%), di (68%) and triglutathionylated forms (9%) with little detectable unmodified M pro (based on abundances form protein deconvolution) (Figure 2A)

10.3389/fcell.2020.00087 95 VarumS.MomciloviO.CastroC.Ben-YehudahaRamalho-SantosJ.NavaraC

[DOI] [PMC free article] [PubMed] [Google Scholar] 159.Kalyane D., Raval N., Maheshwari R., Tambe V., Kalia K., Tekade R.K

In addition, a known factor in pharmacology, such an excessive amount of folate can actually compete with and block the binding of all folate to natural receptors, resulting in down regulation

J Physiol Sci 68 , 1931 (2018)