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The large battery of upregulated cytoprotective genes includes those coding for the endogenous enzyme and nonenzyme antioxidants as well as Phase 2 detoxification enzymes [58]
Moles A, Torres S, Baulies A, Garcia-Ruiz C, Fernandez-Checa JC (2018) Mitochondriallysosomal axis in acetaminophen hepatotoxicity
Current investigations reveal the crucial role of targeting metabolic reprogramming pathways for the amelioration of kidney disease [36], with emphasis on therapies targeting these pathways
Recent evidence has suggested that GPx1 and c-Src tyrosine kinases participate in the phosphorylation of IB which, in response to hypoxia, leads to the activation of NF-B elevated in hydrogen peroxide-treated embryonic fibroblasts [50]
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