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Second, glucose induces a structural shift in GCK into a more active conformation, making the protein more active as glucose concentrations increase (126)

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While tumor-synthesized fatty acids [20, 152, 153] disrupt energy metabolism in NK cells, immunosuppressive immune cells, such as Tregs [20, 111] and M2-like TAMs [88, 152] readily utilize these lipids to sustain their protumor functions

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