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Among antituberculous medications, INH, RIF, EMB, clofazimine, bedaquiline, and delamanid are known to be CYP450 enzyme system substrates or can impact its metabolic activity by induction or inhibition

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Moreover, it was observed that the intracellular Fe 2+ level increased in TBH-treated ARPE-19 cells but that there was no significant change in Fe 2+ after pretreatment with FER-1 or deferoxamine (DFO) (46)

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Another study conducted a comparison of five FRGs namely aconitase 1 (ACO1), N-Ras, MUC1, zinc finger protein 36 (ZFP36), and ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), retrieved from the FerrDb database that have potential applications in the diagnosis, treatment, or prognosis of IPF [206]