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This process is facilitated when tight junction dysfunction occurs or biological barriers are impaired, a phenomenon that is referred to as leaky gut concept [17]

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Our experts also note that too much caffeine can have a negative effect on health and performance, with some individuals being more sensitive to caffeine than others

A further limitation, which has been widely acknowledged (Yamada et al., 2000), is that exogenous LCAC effects are more correctly estimated by determining the LCAC to protein or membrane mole ratios instead of utilizing absolute LCAC concentrations

A previously published case report from the US also described areas of LGE in a patient with PCD who had been non-compliant with regards to L-carnitine supplementation 23