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Although an effective inflammatory response plays a protective role, persistent or excessive inflammatory activity in the central nervous system (CNS) contributes to the pathogenesis of both acute and chronic neurological conditions [48]

First devised at the end of the 1930s, the plaque assay had the advantage that it was both simple and was highly sensitive at detecting small amounts of excess antigen at the lowest concentrations

doi: 10.1155/2015/654594

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In a transgenic model of hair cell ablation in neonatal mice, Lgr5 -positive cells can, to a limited degree, proliferate and regenerate hair cells after damage (Cox et al., In addition to the mitogenic effect exerted by Wnt/-catenin signaling, studies on cochlear development in both mice and chicken suggest that overexpression of -catenin can induce ectopic hair cell formation (Stevens et al., 2003