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In adipose models, reduced NNMT activity has been linked with smaller adipocyte size and diminished fat depots, suggesting a potential role for this inhibitor in fat mass modulation under research conditions

Those following a vegan diet or with a history of heavy alcohol consumption might need higher B12 supplement dosages

These murine models were initially presented with corticosteroids, which reportedly contributed to severe muscular damage in these murine models

It is important to check folate status alongside B12, but folate supplementation should not be started before excluding B12 deficiency, as this may precipitate neurological complications

So when a medic says that someone with PA "can use the stored B12 in their liver", as far as I know, we simply don't know whether this is true or not

Whether that carries over to human blood sugar or waistlines is untested