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GLP-1 medications slow gastric emptying, which can reduce the absorption of oral medications

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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

The net budget impact in the first year is $2.8 million, but there are savings of $4.2 million per year thereafter

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It supports the production of neurotransmitters, which regulate mood and mental clarity