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This study was designed to systematically evaluate the therapeutic potential of GHK-Cu in a dextran sulfate sodium (DSS)-induced murine model of UC, with particular emphasis on elucidating its regulatory effects on the NAD-dependent deacetylase sirtuin-1 (SIRT1)/signal transducer and activator of transcription 3 (STAT3) signaling pathway

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While small-scale early human observations suggest geroprotective potential, large controlled trials do not exist

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We found that exposure to TNF- produced both a concentration-independent and concentration-dependent response in neural activity