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Smolders EJ, et al

Aspartame and the hippocampus: Revealing a bi-directional, dose/time-dependent behavioural and morphological shift in mice. Neurobiol Learn Mem

The authors suggested that the origin of these volatile sulfur-containing compounds is via -lyase reactions on the corresponding cysteine S -conjugates

Other factors that may have influenced these outcomes were species and strain differences, differences in self-administration protocol, and differential impact of blocking D 1 receptors on different neuronal targets at different drug doses

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