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Furthermore, TMAO enhances CaOx crystal deposition via oxidative stress and autophagy-related cell death, impairs renal function, and promotes kidney stones (Kapetanaki et al., 2021) (Figure 9A)

A screen for regulators of survival of motor neuron protein levels

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Gest, A

The full-dose program follows a standard titration from 0.25mg to 2.0mg per week, targeting significant appetite suppression and weight loss

Thus, targeting apoC3 or apoA5 seems to be a potential approach to reduce plasma RC levels, which could be testified in future trials