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Notably, Spry4 deficiency has been shown to alleviate lung injury by activating the calcium/calmodulin dependent protein kinase kinase 2 pathway, contrasting with reports that Spry4 can aggravate sepsis progression (58)

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Int J Med Aromat Plants 2(2):269274 Salaritabar A, Darvishi B, Hadjiakhoondi F, Manayi A, Sureda A, Nabavi SF, Fitzpatrick LR, Nabavi SM, Bishayee A (2017) Therapeutic potential of flavonoids in inflammatory bowel disease: a comprehensive review