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PT-141 typically begins working within 45 minutes to 2 hours after subcutaneous injection
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Chronic oral administration of high doses of levocarnitine to patients with severe renal impairment or end stage renal failure (ESRD) and dialysis may induce an accumulation of the potentially toxic metabolites trimethylamine (TMA) and trimethylamine-N-oxide (TMAO) , as these metabolites are normally excreted in the urine
