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Description
Basically, it is whichever study comes first

Common Side Effects of Vitamin B12 Injections Injection Site Reactions One of the most frequently reported side effects is a reaction at the injection site

(2000) Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study

Krystexxa is FDA-approved specifically for uncontrolled gout, helping where other therapies fall short
The documented research protocol is once daily: 150 mcg from the 10 mg vial, or 2.5 mg from the 50 mg vial
At the 12 mg dose at 48 weeks: -24.2% mean body weight versus -2.1% placebo
