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54 LeistM.GhezziP.GrassoG.BianchiR.VillaP.FratelliM.et al (2004)

Healthcare providers are strongly encouraged to do all of the following: Complete a REMS-compliant education program offered by an accredited provider of continuing education (CE) or another education program that includes all the elements of the FDA Education Blueprint for Health Care Providers Involved in the Management or Support of Patients with Pain

Think of B12 and lipo shots as a support system not a solution on its own
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But lets keep in mind that: After the age of 45, we all observe a decline in endogenous glutathione production

Vopel et al., 2005 Vopel S, Mhlbach H, Skerra A

Many studies also rely on small sample sizes, underscoring the need for larger, more diverse populations to validate efficacy, safety, and patient compliance