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It is characterised by its selective interaction with NNMT (Nicotinamide-N-Methyltransferase) , an enzyme implicated in a range of metabolic and biochemical regulatory processes, making it a valuable reference compound for preclinical and in-vitro research programmes

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Moreover, higher doses of full or partial agonist in the treatment of OUD have been shown to reduce the likelihood of overdose in patients at risk (e.g., those who use more frequently or use higher doses) including those who inject opioids [29, 30, 32,33,34]

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