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doi: 10.1038/sj.onc.1203515 204 LiSDuHWangZZhouLZhaoXZengY

Patients who prefer a fast, well-tolerated infusion with minimal downtime

Graphical Abstract 1 Introduction Late-life depression (LLD) is a common mental disorder among older adults, with a 2024 meta-analysis estimating its global prevalence at 19.2% (Jalali et al., 2024)

The primary difference between ordinary thiamine and TTFD is an extra chemical group called a mercaptan group

NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms