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Right, volcano plot showing relative fold change (log 2 ) in ER-metabolite abundance versus log 10 (P value) from HEK293T cells expressing a sgRNA targeting intergenic region or sgRNA targeting SLC33A1

Dec 21 2017

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Through paracrine signaling, MenSCs increase proliferating cell nuclear antigen (PCNA) expression to promote cell proliferation, inhibit caspase-3-mediated apoptosis to reduce cell death, increase the secretion of anti-inflammatory factors such as IL-10 and keratinocyte growth factor (KGF), and simultaneously suppress proinflammatory cytokines such as IL-1, neutrophil infiltration, and myeloperoxidase (MPO) activity, thereby attenuating pulmonary inflammation and restoring lung function