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Human studies have mainly described pharmacokinetics, safety, and tolerability, rather than demonstrating strong clinical effectiveness

Preclinical studies showed preferential reduction of abdominal and visceral adipose tissue, suggesting favorable body composition changes even when total weight loss is moderate

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When tirzepatide activates the GLP-1 receptor, several beneficial effects occur: Increased Insulin Secretion : In response to high blood glucose levels, the pancreas secretes more insulin

Much of the current evidence is preclinical (cell and animal studies), and human data is still limited

Tirzepatide produced 33.9% fat mass loss in SURMOUNT-1