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This combined approach not only mitigated disease activity, but also reinforced the antioxidant system, accentuating ozone therapeutic complementarity [61]

Carnosine conjugates lipid peroxides to provide oxidative protection (243), and has also shown potential, as carnosine supplementation resulted in potential symptomatic benefits in a clinical trial enrolling patients with PD (244)

The mitochondrial AR is involved in regulating mtDNA levels and mtDNA transcription and translation

Ann Neurol 32:S128S132

As demonstrated by Kurimchack et al., high endogenous levels of the MDR1 protein resulted in a significant decrease in the efficacy of Cereblon-based PROTAC dBET6 when compared with PROTACs-nave cancer cells with low expression of MDR1 201

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