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Description
Fractionated radiation induces an increase in IGF1 secretion level and gradually up-regulates IGF1R expression in cancer stem cells (GSCs) (Osuka et al., 2013

It is a dimer form, which is quite common

Hepatol 64, 265267 (2016)

They activate gene expression via intermediate signaling proteins such as Src, Ras, Rac/cdc42, and mixed lineage kinase protein families

Carvalho Pereira A, Violante IR, Mouga S, Oliveira G, Castelo-Branco M
However, constitutive activation of these signaling pathways leads to the uncontrolled proliferation of cancer cells and causes impairment in the programmed cell death, which represents the major causative factors for the development and progression of cancer [340]
