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Peripheral opioid receptors, particularly upregulated during inflammation [59], offer a rationale for topical application in wounds, providing localized analgesia with a minimum systemic exposure

10.1074/jbc.M109541200 173 ValiR.ShirvanianK.FarkhondehT.AschnerM.SaminiF.SamarghandianS

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The rate of pancreatic secretion is decreased, which means decreased amylase, trypsin, lipase, sodium bicarbonate, and other enzymes

Rare but Serious Side Effects: Allergic reactions such as swelling, rash, or difficulty breathing

Loss of Parkinsons disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c