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Furthermore, immune-mediated pathways, including sclerostin inhibition of Wnt signaling and FGF-23 dysregulation, have emerged as critical regulators of mineral metabolism and potential therapeutic targets beyond conventional phosphate management (123, 124)

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Taken together, human in vitro and in vivo studies suggest that CYP3A4 plays a minor role in the bioactivation of low dose APAP

The most commonly observed side effects include mild injection-site irritation and nausea, which subside within the first week or two, especially at lower doses