glp-1 receptor agonists for weight loss glp-1_analogs [TUSOM How GLP-1 Receptor Agonists Evolved

Since the expansion of approved uses to include weight loss, these medications have become increasingly popular

Endogenous GLP-1R signaling exerts a physiologically relevant effect on BP control, which may be attributable, in part, to its tonic actions on proximal tubule Na/H mediated sodium reabsorption, and the intrarenal renin-angiotensin II system [67]

For the GLP-1 receptor agonists, the pooled event rates ranged from 1.6 to 2.7 per 1,000 patient-years

Cell Rep 33:108271

"I think this should be the very first step in someone's journey if they're interested in GLP-1s," Reitano said

You might be a candidate if: You have a BMI of 30 or higher (classified as obesity) You have a BMI of 27 or higher with at least one weight-related condition such as: High blood pressure High cholesterol Sleep apnea Fatty liver disease Polycystic ovary syndrome (PCOS) Joint problems related to excess weight Clinical trials have shown that Mounjaro can help people lose an average of 15-20% of their body weight over about a year, which is significantly more than most other anti-obesity medications