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Similar observations were made in aortic tissue slices, where FOXO4-DRI treatment led to increased expression of p-P53, mainly localized in the cytoplasm (Figures 5F,G)

[DOI] [PubMed] [Google Scholar] 97.Prince RL, Smith M, Dick IM, Price RI, Webb PG, Henderson NK, Harris MM

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Depending on your genotype, this can have a modest to meaningful effect on adipokine signaling, insulin sensitivity, and metabolic regulation