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Furthermore, the sleep-dependent visual texture discrimination task was used and test following sleep was associated with significantly better activation in an area of primary visual cortex corresponding to the visual target location [29]

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This observation strongly supports that IL-1R1 signalling is a key factor that prevents wound closure in the diabetic condition and it prompted us to explore IL-1R1 inhibition through the delivery of IL-1Ra as a possible treatment for chronic wounds

These findings imply that urolithin A requires both AhR- and Nrf2-dependent pathways to enhance the TJ barrier

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