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In summary, methionine restriction selectively exacerbates the oxidative stress in cancer cells by targeting their antioxidant metabolic vulnerability-particularly through disrupting glutathione synthesis-thereby ultimately inducing cell death

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10.1001/jama.2008.9292009 265 WenningG.LitvanI.JankovicJ.GranataR.MangoneC.McKeeA.et al (1998)

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Oxidant and redox signaling in vascular oxygen sensing mechanisms: basic concepts, current controversies, potential importance of cytosolic NADPH