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Summary Multiple lines of evidence indicate that dysregulation of any of several components of the UPS, or mutations in genes that encode them, exacerbate AD progression and are deleterious to the recovery of function after SCI

& Beckmann, G

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The changes in SOD activity in a particular compartment may lead to the generation of a hydrogen peroxide concentration gradient and the subsequent activation of redox sensitive pathways

These models help scientists explore biological processes related to connective tissue biology, angiogenic signaling, and nitric oxide pathway regulation