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ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood-brain barrier integrity after traumatic brain injury

67 Non-proliferative astrogliosis typically occurs in neural tissue that is responding to a pathology but is not overtly damaged and retains its basic tissue architecture, for example (i) during diffuse neuroinflammation caused by peripheral exposure to microbial antigens such as lipopolysaccharide (LPS), 68,69 (ii) in tissue regions that are at a distance from focal lesions (diaschisis) caused by stroke, trauma or autoimmune attack, 8,70 or (iii) in tissue undergoing neurodegenerative changes

This trial evaluated the safety and tolerability of both single ascending doses and multiple ascending doses of Molgramostim in humans

More recent studies have suggested that the effectiveness of parenteral and high-dose oral B12 (1 mg/d) is similar in correcting serum concentrations of vitamin B12, though the evidence is of low quality